Beilstein J. Org. Chem.2015,11, 2721–2726, doi:10.3762/bjoc.11.293
. The aminooxygenation product could be converted into the corresponding alcohol or free amine through the cleavage of the N–O or C–N bond of the N-hydroxyphthalimide moiety.
Keywords: aminooxygenationofstyrenes; copper catalysts; N-fluorobenzenesulfonimide; N-hydroxyphthalimide derivatives
. For 4-methoxystyrene (1r), no aminooxygenation reaction occurred.
Based on these experimental results and our previous investigations [42][43][44][45][46][48], a plausible mechanism for the copper-catalyzed three-component aminooxygenationofstyrenes with NFSI an NHPI is shown in Scheme 2. Initially
the cleavage of the N–O or C–N bond of the NHPI moiety. Further studies are underway in our lab.
Bioactive compounds containing 1,2-aminoalcohol motif.
The copper-catalyzed three-component aminooxygenationofstyrenes with NFSI and NHPI derivatives. Reaction conditions: 1 (0.9 mmol, 3.0 equiv), NFSI